Protein/Protein Interactions (PDZ) in Proximal Tubules
نویسندگان
چکیده
منابع مشابه
PDZ interactions and proximal tubular phosphate reabsorption.
In adults, the extent of renal reabsorption of P(i) and consequently the extent of urinary excretion of phosphate are to a large extent determined by the abundance of the Na-P(i) cotransporter NaPi-IIa (SLC34A1). Localization of this cotransporter is restricted to the apical membrane of proximal tubular cells, and its abundance is controlled by a number of factors and pathophysiological conditi...
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This paper describes experiments designed to evaluate Na+ and C1transport in isolated proximal straight tubules from rabbit kidneys. When the perfusing solution was Krebs-Ringer buffer with 25 mM HCO8 (KRB) and the bath contained KRB plus 6 % albumin, net volume reabsorption (J,, nl min-' mm-') was -0.46 4 0.03 (SEM); V., the spontaneous transepithelial potential difference, was -1.13 + 0.05 mV...
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The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na+/H+ exchange and basolateral Na+:HCOcotransport systems in metabolic acidosis. Proximal tubular suspensions were prepared from rabbit kidney cortex and incubated in acidic (A) or control (C) media (pH 6.9 vs 7.4, 5% C02) for 2 h. Brush border membrane (BBM) and basola...
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TUNE, BRUCE M., AND MAURICE B. BURG. Glucose transport by proximal renal tubuler. Am. J. Physiol. 221(Z) : 580-585. 197 1 .-Glucose transport was studied in isolated, perfused rabbit proximal renal tubules. Glucose was actively transported out of the lumen of both the convoluted and straight portions. The rate of glucose transport was, however, much greater in the convoluted portion than in the...
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Volume, osmolality, and concentrations for Na, Cl, and raffinose have been measured as a function of time in standing droplets within rat intermediate and late proximal tubules. Standing droplet reabsorption proceeds without the development of a measurable osmotic difference across the epithelium. After 140 s of tubular exposure, droplet-to-plasma concentration differences are observed for raff...
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ژورنال
عنوان ژورنال: Journal of Membrane Biology
سال: 2005
ISSN: 0022-2631,1432-1424
DOI: 10.1007/s00232-005-0738-7